Details

Autor(en) / Beteiligte

• Porretta, GC
• Fioravanti, R
• Biava, M
• Cirilli, R
• Simonetti, N
• Villa, A
• Bello, U
• Faccendini, P
• Tita, B

Titel

Research on antibacterial and antifungal agents. X. Synthesis and antimicrobial activities of 1-phenyl-2-(1 H-azol-1-yl) ethane derivatives. Anticonvulsant activity of 1-(4-methylphenyl)-2-(1 H-imidazol-1-yl) ethanol

Ist Teil von

• European journal of medicinal chemistry, 1993, Vol.28 (10), p.749-760

Ort / Verlag

Oxford: Elsevier Masson SAS

Erscheinungsjahr

1993

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• The synthesis and antimicrobial activity of new phenylazolylethane derivatives are reported. Antimicrobial data in comparison with those obtained with miconazole, fluconazole, enilconazole, imazalil sulfate, pipemidic acid and minocycline showed that tested compounds generally possessed poor or weak activity. Toxicity and anticonvulsant activity of 1-(4-methylphenyl)-2-(1 H-imidazol-1-yl)ethanol and structural likeness to Denzimol were also tested. The obtained results showed interesting anticonvulsant activity but only on the supraspinal region.