Details

Autor(en) / Beteiligte

• Porretta, GC
• Biava, M
• Fioravanti, R
• Fischetti, M
• Melino, C
• Venza, F
• Bolle, P
• Tita, B

Titel

Research on antibacterial and antifungal agents. VIII. synthesis and antimicrobial activity of 1,4-diarylpyrroles

Ist Teil von

• European journal of medicinal chemistry, 1992, Vol.27 (7), p.717-722

Ort / Verlag

Oxford: Elsevier Masson SAS

Erscheinungsjahr

1992

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The synthesis and the antimicrobial activity of 1,4-diarylpyrroles are reported. The obtained data in comparison with pyrrolnitrin show that many acid derivatives 4 exhibit a selective activity against some strains of Candida spp and poor activity against strains of Candida albicans. All ester derivatives 3 are inactive. The results obtained are discussed on the basis of structure-activity relationships.