Details

Autor(en) / Beteiligte

• Le Chevalier, Thierry
• Arriagada, Rodrigo
• Quoix, Elizabeth
• Ruffie, Pierre
• Martin, Michel
• Douillard, Jean-Yves
• Tarayre, Michèle
• Lacombe-Terrier, Marie-José
• Laplanche, Agnès

Titel

Radiotherapy alone versus combined chemotherapy and radiotherapy in unresectable non-small cell lung carcinoma

Ist Teil von

• Lung cancer (Amsterdam, Netherlands), 1994-03, Vol.10, p.S239-S244

Ort / Verlag

Ireland: Elsevier Ireland Ltd

Erscheinungsjahr

1994

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• We report the results observed in a large randomized study comparing radiotherapy alone to combined radiotherapy and chemotherapy in unresectable squamous cell and large cell lung carcinoma. Radiation dose was 65 Gy in both groups and chemotherapy included vindesine, cyclophosphamide, cisplatin and lomustine. One hundred seventy-seven patients received radiotherapy alone, and 176 received the combined treatment. The 2-year survival rate was 14% for patients receiving radiotherapy vs. 21% for patients receiving the combined treatment ( P = 0.02). The distant metastasis rate was significantly lower in the group receiving the combined treatment ( P < 0.001). Local control at 1 year was poor in both groups (17% and 15%, respectively) and remains a major problem in locally advanced non-small cell lung cancer.