Details

Autor(en) / Beteiligte

• Ribeiro, Carlos M.R.
• de Melo, Sebastião J.
• Bonin, Martine
• Quirion, Jean-Charles
• Husson, Henri-Philippe

Titel

Asymmetric synthesis. XXXIV. Synthesis of spiro-piperidine derivatives via the CN(R,S) method

Ist Teil von

• Tetrahedron letters, 1994-09, Vol.35 (39), p.7227-7230

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

1994

Link zum Volltext

Quelle

ScienceDirect

Beschreibungen/Notizen

• 5-Aza-spiro-[3,5] nonane and 6-aza-spiro-[4,5] decane derivatives 5 and 9 have been prepared from 2-cyano-6-phenyloxazolopiperidine synthon 2b via alkylation followed by cyclisation of the resulting halogeno aminonitrile under dissolving metal conditions. 5-Aza-spiro-[3,5] nonane 5a, 6-aza-spiro-[4,5] decane 5b and tricyclic enamine 8 were prepared from 3a and 3b under dissolving metal conditions.