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Chromatographic resolution and pharmacological investigation of some imidazole derivatives
Ist Teil von
Journal of Chromatography A, 1996-04, Vol.729 (1), p.1-4
Ort / Verlag
Elsevier B.V
Erscheinungsjahr
1996
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
Some N-phenylethylimidazoles have a chiral carbon atom in their structure. These compounds were obtained by non-stereoselective synthesis and their pharmacological activity was always tested on the racemic mixtures. The proposed HPLC method allowed the chiral resolution of RF29, denzimol and reduced nafimidone by using a Chiracel OD-H column. The enantiomers of each compound were separately collected and their pharmacological activity was tested on the guinea pig ileum and the rabbit jejunum.