Details

Autor(en) / Beteiligte

• Quaglia, M.G.
• Bossù, E.
• Porretta, G.C.
• Biava, M.
• Fioravanti, R.
• Romanelli, L.
• Leonardi, A.

Titel

Chromatographic resolution and pharmacological investigation of some imidazole derivatives

Ist Teil von

• Journal of Chromatography A, 1996-04, Vol.729 (1), p.1-4

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

1996

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Some N-phenylethylimidazoles have a chiral carbon atom in their structure. These compounds were obtained by non-stereoselective synthesis and their pharmacological activity was always tested on the racemic mixtures. The proposed HPLC method allowed the chiral resolution of RF29, denzimol and reduced nafimidone by using a Chiracel OD-H column. The enantiomers of each compound were separately collected and their pharmacological activity was tested on the guinea pig ileum and the rabbit jejunum.