Details

Autor(en) / Beteiligte

• Archambault, Andre P.
• Pare, Pierre
• Bailey, Robert J.
• Navert, Henri
• Williams, C.Noel
• Freeman, Hugh J.
• Baker, Selwyn J.
• Marcon, Norman E.
• Hunt, Richard H.
• Sutherland, Lloyd
• Kepkay, David L.
• Saibil, Fred G.
• Hawken, Katherine
• Farley, Alain
• Levesque, Denis
• Ferguson, James
• Westin, Jan-Ake

Titel

Omeprazole (20 mg daily) versus cimetidine (1200 mg daily) in duodenal ulcer healing and pain relief

Ist Teil von

• Gastroenterology (New York, N.Y. 1943), 1988-05, Vol.94 (5), p.1130-1134

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

1988

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• We conducted a double-blind, randomized, parallel group study in 169 patients with acute duodenal ulcers to compare omeprazole, 20 mg daily, with cimetidine, 600 mg twice daily. After 2 wk, 58% of the omeprazole-treated patients and 46% of the cimetidine-treated patients were completely healed (p = 0.056). After 4 and 6 wk 84% and 88% healed with omeprazole, and 80% and 89% healed with cimetidine (p = NS). After 2 wk, pain was completely gone in 62% of the omeprazole-treated patients versus 46% of the cimetidine-treated patients (p = 0.04). Clinical or laboratory adverse events were reported in 6 (7%) of the omeprazole-treated patients and 11 (13%) of the cimetidine-treated patients (p = NS). An adverse event caused withdrawal of 1 patient on omeprazole (anxiety and depression) and 2 patients on cimetidine (diarrhea and fall in hemoglobin). We conclude that omeprazole (20 mg daily) resulted in a trend toward more rapid ulcer healing compared with a relatively high dose of cimetidine (600 mg b.i.d.), and was preferred by patients for relief of ulcer pain.