Details

Autor(en) / Beteiligte

• Patwardhan, Rashmi V.
• Yarborough, Garland W.
• Desmond, Paul V.
• Johnson, Raymond F.
• Schenker, Steven
• Speeg, K.V.

Titel

Cimetidine spares the glucuronidation of lorazepam and oxazepam

Ist Teil von

• Gastroenterology (New York, N.Y. 1943), 1980-11, Vol.79 (5), p.912-916

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

1980

Quelle

MEDLINE

Beschreibungen/Notizen

• Lorazepam (Ativan) disposition and elimination were studied in 8 normal subjects before and after 1 wk of cimetidine therapy, 300 mg taken orally four times a day. In 4 of these 8 normal subjects the disposition and elimination of oxazepam (Serax) were also studied before and after similar treatment with cimetidine. Cimetidine did not alter the elimination of either lorazepam or oxazepam. Since both drugs are eliminated exclusively after conjugation as glucuronide, this study demonstrates a relative sparing of this pathway of biotransformation of drugs in subjects receiving cimetidine.