Details

Autor(en) / Beteiligte

• Grimes, J.A.
• Fraser, S.P.
• Stephens, G.J.
• Downing, J.E.G.
• Laniado, M.E.
• Foster, C.S.
• Abel, P.D.
• Djamgoz, M.B.A.

Titel

Differential expression of voltage-activated Na + currents in two prostatic tumour cell lines: contribution to invasiveness in vitro

Ist Teil von

• FEBS letters, 1995-08, Vol.369 (2), p.290-294

Ort / Verlag

England: Elsevier B.V

Erscheinungsjahr

1995

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• The voltage-gated ionic currents of two rodent prostatic cancer cell lines were investigated using the whole-cell patch clamp technique. The highly metastatic Mat-Ly-Lu cells expressed a transient, inward Na + current (blocked by 600 nM tetrodotoxin), which was not found in any of the weakly metastatic AT-2 cells. Although both cell lines expressed a sustained, outward K + current, this occurred at a significantly higher density in the AT-2 than in the Mat-Ly-Lu cells. Incubation of the Mat-Ly-Lu cell line with 600 nM tetrodotoxin significantly reduced the invasive capacity of the cells in vitro. Under identical conditions, tetrodotoxin had no effect on the invasiveness of the AT-2 cells.