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In adjuvant-induced polyarthritis, rat liver lysosomes release acid phosphatase and β-glucuronidase more slowly than normal. The effect appears on the first day and persists for at least 2 weeks. Slowed release seems to reflect altered membrane stability rather than decreased enzyme synthesis, since there are insignificant differences between enzyme activities of detergent-treated lysosomes from normal and adjuvantinduced arthritic rats. Oral administration of either cycloleucine or aspirin partially normalizes the enzyme release. These results indicate that membrane labilization may be a factor in diminishing the expression of tissue injury.