Details

Autor(en) / Beteiligte

• Zanotelli, Patrícia
• Locateli, Gelvani
• Vecchia, Cristian D.
• Gomes, Denise B.
• Oliveira, Beatriz M. M.
• Lutinski, Junir A.
• Predebom, Ana Júlia
• Miorando, Daniela
• Zanatta, Maria E. C.
• Steffler, Amanda M.
• Carteri, Camila S.
• Santos, Maria F. C.
• Barison, Andersson
• Silva, Luisa M.
• Andrade, Sérgio F.
• Roman Junior, Walter A.

Titel

Gastroprotective Potential of the Hydroalcoholic Extract from Jacaranda puberula in Mice

Ist Teil von

• Revista brasileira de farmacognosia, 2020-12, Vol.30 (6), p.838-843

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2020

Quelle

SpringerLink

Beschreibungen/Notizen

• The gastroprotective effects of Jacaranda puberula Cham., Bignoniaceae, a tree native to the Brazilian Atlantic Forest, were evaluated using two models of acute ulceration in mice: acidified ethanol- and non-steroidal anti-inflammatory-induced ulceration. The mice were divided into five groups and treated orally with vehicle, carbenoxolone, or hydroalcoholic extract obtained from the tested plant (3, 30, or 300 mg/kg). Results showed that the doses of 300 mg/kg decreased both acidified ethanol- and indomethacin-induced ulceration by 89% and 33%, respectively, compared to the vehicle ( p  < 0.001). These results were similarly to those obtained for the carbenoxolone-treated group. Gastroprotection was confirmed by histological analysis. The gastroprotective mechanisms involve reductions in inflammatory and oxidative stress markers, including a reduction in myeloperoxidase activity, along with increases in glutathione levels and superoxide dismutase activity. Jacaranone and verbascoside were identified as the active components. Graphical abstract