Neurotoxicity research, 2018-05, Vol.33 (4), p.824-836
2018
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- Autor(en) / Beteiligte
- Titel
- Restoration of Cognitive Performance in Mice Carrying a Deficient Allele of 8-Oxoguanine DNA Glycosylase by X-ray Irradiation
- Ist Teil von
- Neurotoxicity research, 2018-05, Vol.33 (4), p.824-836
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Environmental stressors inducing oxidative stress such as ionizing radiation may influence cognitive function and neuronal plasticity. Recent studies have shown that transgenic mice deficient of DNA glycosylases display unexpected cognitive deficiencies related to changes in gene expression in the hippocampus. The main objectives of the present study were to determine learning and memory performance in C57BL/6NTac 8-oxoguanine DNA glycosylase 1 (Ogg1) +/− (heterozygote) and Ogg1 +/+ (wild type, WT) mice, to study whether a single acute X-ray challenge (0.5 Gy, dose rate 0.457 Gy/min) influenced the cognitive performance in the Barnes maze, and if such differences were related to changes in gene expression levels in the hippocampus. We found that the Ogg1 +/− mice exhibited poorer early-phase learning performance compared to the WT mice. Surprisingly, X-ray exposure of the Ogg1 +/− animals improved their early-phase learning performance. No persistent effects on memory in the late-phase (6 weeks after irradiation) were observed. Our results further suggest that expression of 3 ( Adrb1 , Il1b , Prdx6 ) out of in total 35 genes investigated in the Ogg1 +/− hippocampus is correlated to spatial learning in the Barnes maze.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1029-8428eISSN: 1476-3524DOI: 10.1007/s12640-017-9833-7Titel-ID: cdi_crossref_primary_10_1007_s12640_017_9833_7
- Format
- –
- Schlagworte
- Analysis of Variance, Animals, Biomedical and Life Sciences, Biomedicine, Cell Biology, Cognition Disorders - genetics, Cognition Disorders - therapy, Disease Models, Animal, DNA Glycosylases - deficiency, DNA Glycosylases - genetics, Dose-Response Relationship, Radiation, G-Protein-Coupled Receptor Kinase 2 - genetics, G-Protein-Coupled Receptor Kinase 2 - metabolism, Gene Expression - genetics, Gene Expression - radiation effects, Interleukin-1beta - genetics, Interleukin-1beta - metabolism, Male, Maze Learning - radiation effects, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neurobiology, Neurochemistry, Neurology, Neurosciences, Original Article, Peroxiredoxin VI - genetics, Peroxiredoxin VI - metabolism, Pharmacology/Toxicology, Reaction Time - radiation effects, Recovery of Function - genetics, Recovery of Function - radiation effects, RNA, Messenger - metabolism, X-Ray Therapy