Journal of cardiovascular translational research, 2014-02, Vol.7 (1), p.91-100
2014
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- Autor(en) / Beteiligte
- Titel
- Randomized Comparison of Ticagrelor versus Prasugrel in Patients with Acute Coronary Syndrome and Planned Invasive Strategy—Design and Rationale of the Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment (ISAR-REACT) 5 Trial
- Ist Teil von
- Journal of cardiovascular translational research, 2014-02, Vol.7 (1), p.91-100
- Ort / Verlag
- Boston: Springer US
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- In acute coronary syndromes (ACS), a dual antiplatelet regimen with an adenosine diphosphate (ADP) receptor antagonist plus aspirin has become the cornerstone of treatment. The third-generation thienopyridine prasugrel and the cyclopentyl-triazolo-pyrimidine ticagrelor provide a greater, more rapid and consistent platelet inhibition compared to their predecessor clopidogrel. Based on their advantages over clopidogrel in two landmark studies, both drugs received a class I recommendation for their use in ACS patients with and without ST segment elevation. Due to differences in ACS populations and conditions investigated, the relative merits of ticagrelor versus prasugrel in the treatment of ACS patients with planned invasive strategy cannot be reliably estimated from independent trials. To date, no direct head-to-head comparison of ticagrelor and prasugrel in terms of clinical outcome exists. The aim of this multicenter, randomized, open-label trial is to assess whether ticagrelor is superior to prasugrel in ACS patients with planned invasive strategy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1937-5387eISSN: 1937-5395DOI: 10.1007/s12265-013-9527-3Titel-ID: cdi_crossref_primary_10_1007_s12265_013_9527_3
- Format
- –
- Schlagworte
- Acute Coronary Syndrome - blood, Acute Coronary Syndrome - diagnosis, Acute Coronary Syndrome - mortality, Acute Coronary Syndrome - therapy, Adenosine - administration & dosage, Adenosine - adverse effects, Adenosine - analogs & derivatives, Biomedical Engineering and Bioengineering, Biomedicine, Cardiology, Clinical Protocols, Coronary Thrombosis - etiology, Coronary Thrombosis - mortality, Coronary Thrombosis - prevention & control, Drug Administration Schedule, Fibrinolytic Agents - administration & dosage, Fibrinolytic Agents - adverse effects, Germany, Human Genetics, Humans, Medicine, Medicine & Public Health, Myocardial Infarction - etiology, Myocardial Infarction - mortality, Percutaneous Coronary Intervention - adverse effects, Percutaneous Coronary Intervention - instrumentation, Piperazines - administration & dosage, Piperazines - adverse effects, Platelet Aggregation Inhibitors - administration & dosage, Platelet Aggregation Inhibitors - adverse effects, Prasugrel Hydrochloride, Research Design, Stents, Stroke - etiology, Stroke - mortality, Thiophenes - administration & dosage, Thiophenes - adverse effects, Time Factors, Time-to-Treatment, Treatment Outcome