Details

Autor(en) / Beteiligte

• WANG, Tong
• LI, Qing
• ZHANG, Gui-feng
• ZHOU, Gang
• YU, Xin
• ZHANG, Jing
• WANG, Xiu-mei
• TANG, Zhi-hui

Titel

Comparative evaluation of a biomimic collagen/ hydroxyapatite/β-tricaleium phosphate scaffold in alveolar ridge preservation with Bio-Oss Collagen

Ist Teil von

• Frontiers of materials science, 2016-06, Vol.10 (2), p.122-133

Ort / Verlag

Beijing: Higher Education Press

Erscheinungsjahr

2016

Quelle

Springer LINK 全文期刊数据库

Beschreibungen/Notizen

• Bone scaffolds are critical in current implant and periodontal regeneration approaches. In this study, we prepared a novel composite type-I collagen and hydroxyapatite （HA）/β-tricaleium phosphate （TCP） scaffold （CHTS） by incorporating type-I collagen and bovine calcined bone granules, prepared as a mixture of 50% HA and 50% TCP, by freeze drying. We then characterized the CHTS and determined its cytotoxic effects. Additionally, ridge preservation experiments were carried out to evaluate the clinical effects of the CHTS. The results demonstrated that the composite scaffolds had good surface morphology and no cytotoxicity. Additionally, an in vivo experiment in an animal model showed that the CHTS performed equally as well as Bio-Oss Collagen, a widely used bone graft in ridge preservation. These findings revealed that the CHTS, which contained natural constituents of bone, could be used as a scaffold for bone regeneration and clinical use.