Details

Autor(en) / Beteiligte

• Tian, Xiao-ying
• Liu, Liang

Titel

Drug Discovery Enters A New Era with Multi-Target Intervention Strategy

Ist Teil von

• Chinese journal of integrative medicine, 2012-07, Vol.18 (7), p.539-542

Ort / Verlag

Heidelberg: Chinese Association of Traditional and Western Medicine

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• In the past century, as medical research has become increasingly precise, it has become clear that the incidence and progression of many diseases involve multiple factors and pathologies; this is particularly true for the degenerative and metabolic diseases facing industrialized societies. At the same time, it becomes increasingly clear that single-target action drugs cannot effectively treat these diseases. Researchers are looking toward the chemical industry as well as traditional herbal medicines to find multi-target interventions. Thus, a new era in drug discovery has begun. Specifically, three approaches have proven effective in seeking multi-target drugs. These are： （1） designing drugs with multiple components; （2） discovering drugs through the study of synergistic compound-compound interactions in medicinal herbs or among chemical drugs and herbal components; and （3） developing drugs to tackle complex multi-component diseases. The authors conclude that there is an increasing need for multi-component remedies to treat the complex chronic diseases afflicting modern populations. Given this situation and the growing body of evidence that these new approaches are effective, multi-target intervention appears to have great potential for discovering, designing, and developing effective new drugs for today＇s diseases.