Details

Autor(en) / Beteiligte

• Gan’shina, T. S.
• Kurza, E. V.
• Maslennikov, D. V.
• Kurdyumov, I. N.
• Gnezdilova, A. V.
• Kostochka, L. M.
• Mirzoyan, R. S.

Titel

A New Piperidine Derivative with Antiserotonin Anti-Migraine Activity and Its Combination with Picamilon

Ist Teil von

• Pharmaceutical chemistry journal, 2023-07, Vol.57 (4), p.518-522

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A new serotonin antagonist with anti-migraine activity, 2,3,4-trimethoxy- N -(2,2,6,6-tetramethylpiperidin-4-ylidene)benzohydrazide hydrochloride (LK-1033), was identified as a result of screening piperidine derivatives. Experiments on non-linear rats with registration of local blood flow in the cerebral cortex and blood flow in the carotid artery revealed the ability of LK-1033 to attenuate changes in cerebral blood flow caused by serotonin. However, this compound lowered the initial level of cerebral circulation. Combination of LK-1033 with the anti-ischemic drug picamilon was proposed to neutralize this negative effect. The combination containing LK-1033 and picamilon exhibited both antiserotonin cerebrovascular activity and antiischemic activity.