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GMP production of 68Ga-labelled DOTA-NOC on IBA Synthera
Ist Teil von
Journal of radioanalytical and nuclear chemistry, 2015-08, Vol.305 (2), p.501-506
Ort / Verlag
Dordrecht: Springer Netherlands
Erscheinungsjahr
2015
Link zum Volltext
Quelle
SpringerLink
Beschreibungen/Notizen
68
Ga labelled peptides are increasingly being used clinically due to widespread availability of
68
Ge/
68
Ga generators and their recognised importance in the diagnosis of neuroendocrine tumours. A simple and reproducible GMP-compliant process for labelling peptides with generator-produced
68
Ga is crucial to meet current pharmaceutical requirements. Here, we describe the development of a cassette-based
68
Ga-radiolabelling process using an automated commercial synthesizer coupled with a standard
68
Ge/
68
Ga generator. The radiolabeled somatostatin analogue [
68
Ga]DOTA-NOC was successfully synthesized in about 30 min with 80.3 ± 3.20 % of decay corrected radiochemical yield. The process is easily adaptable to the labelling of other peptides such as DOTA-TOC or DOTA-TATE for diagnosis or therapy.