Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
The 3′UTR NFKBIA Variant Is Associated with Extensive Colitis in Hungarian IBD Patients
Ist Teil von
Digestive diseases and sciences, 2009-02, Vol.54 (2), p.351-359
Ort / Verlag
Boston: Springer US
Erscheinungsjahr
2009
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Purpose
In previous studies the
NFKBIA
3′UTR (untranslated region) AA genotype was associated with Crohn’s disease (CD), while the
NFKB1
-94ins/delATTG mutation increased the risk for ulcerative colitis (UC). The aim of our study was to investigate these two polymorphisms and patients’ response to medical therapy and/or disease phenotype in Hungarian inflammatory bowel disease (IBD) patients.
Methods
NFKBIA
3′UTR- and
NFKB1
-94ins/delATTG polymorphisms were investigated in 415 unrelated IBD patients (CD: 266 patients, mean age 35.2 ± 12.1 years, duration 8.7 ± 7.5 years; UC patients: 149, mean age 44.4 ± 15.4 years, duration 10.7 ± 8.9 years) and 149 controls by PCR-restriction fragment length polymorphism (RFLP) analysis. Detailed clinical phenotypes were determined by reviewing the medical charts.
Results
The
NFKBIA
3′UTR and
NFKB1
-94ins/delATTG genotypes and allele frequencies were not significantly different among IBD and controls. In patients with UC, the 3′UTR GG genotype was associated with extensive colitis (55.3 vs. 29.4%, odds ratio 2.97, 95% confidence interval 1.45–6.08). The presence of variant alleles did not predict response to steroids, infliximab, or need for surgery.
Conclusions
The
NFKBIA
3′UTR GG genotype was associated with an increased risk for extensive colitis in Hungarian patients. In contrast, variant alleles did not predict response to medical therapy or need for surgery.