Details

Autor(en) / Beteiligte

• Bugge, S.
• Skjønsfjell, E. M.
• Willumsen, F. B.
• Sundby, E.
• Hoff, B. H.

Titel

Improved and Scalable Preparation of 6-Bromo-4-Chlorothieno[2,3-d]Pyrimidine

Ist Teil von

• Chemistry of heterocyclic compounds (New York, N.Y. 1965), 2014-11, Vol.50 (8), p.1177-1187

Ort / Verlag

Boston: Springer US

Erscheinungsjahr

2014

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A practical, robust and scalable synthesis of 6-bromo-4-chlorothieno[2,3-d]pyrimidine starting from cheap bulk chemicals has been developed. The method involves four synthetic steps: Gewald reaction, pyrimidone formation, bromination, and chlorination. The process relies on standard laboratory equipment, allowing to obtain the product in an overall yield of 49% without using chromatography for purification of the product and intermediates.