Details

Autor(en) / Beteiligte

• Ehsan G. El-Ghoneimy Mohamed A. Hassan Mahmoud F. El-Bestar Omar M. Othman Karim N. Mashhour

Titel

A dosimetric comparative study between conformal and intensity modulated radiation therapy in the treatment of primary nasopharyngeal carcinomas： the Egyptian experience

Ist Teil von

• The Chinese-German journal of clinical oncology, 2012-11, Vol.11 (11), p.626-631

Ort / Verlag

Berlin/Heidelberg: Springer-Verlag

Erscheinungsjahr

2012

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objective： The study is a comparative study, the aim of which is to compare 3D conformal radiation therapy （3D-CRT） and intensity modulated radiation therapy （IMRT） in treating nasopharyngeal carcinomas; dosimetrically evaluating and comparing both techniques as regard target coverage and doses to organs at risk （OAR）. Methods： Twenty patients with nasopharyngeal carcinoma were treated by 3D-CRT technique and another 20 patients were treated by IMRT. A dosimetric comparison was done by performing two plans for the same patient using Eclipse planning system （version 8.6）. Results： IMRT had a better tumor coverage and conformity index compared to 3D-CRT plans （P value of 0.001 and 0.004）, respectively. As for the dose homogeneity it was also better in the IMRT plans and the reason for this was attributed to the dose inhomogeneity at the photon/electron junction in the 3D-CRT plans （P value 0.032）. Also, doses received by the risk structures, particularly parotids, was significantly less in the IMRT plans than those of 3D-CRT （P value 0.001）. Conclusion： IMRT technique was clearly able to increase the dose delivery to the target volume, improve conformity and homogeneity index and spare the parotid glands in comparison to 3D-CRT technique.