Details

Autor(en) / Beteiligte

• Baytas, Sultan Nacak
• Inceler, Nazan
• Yılmaz, Akın

Titel

Synthesis, cytotoxicity, and molecular properties prediction of novel 1,3-diarylpyrazole derivatives

Ist Teil von

• Medicinal chemistry research, 2013-10, Vol.22 (10), p.4893-4908

Ort / Verlag

Boston: Springer US

Erscheinungsjahr

2013

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• A novel combinatorial library of ester and amide derivatives of 1,3-diarylpyrazoles was designed and synthesized. Anticancer activities of these compounds were assessed against MCF7, MDA-MB-231, HeLa, Raji, and HL60 human cancer cells by MTT assay. Out of these, compounds 4c and 5f were found as the most promising anticancer agents with IC 50 values of 8.12 and 9.63 μM in Raji cells, respectively. All compounds exhibited suitable drug-like characteristics according to Lipinski’s rule.