Details

Autor(en) / Beteiligte

• Bashir, Rafia
• Ovais, Syed
• Yaseen, Shafiya
• Hamid, Hinna
• Alam, M. S.
• Samim, Mohammed
• Javed, Kalim

Titel

Synthesis and blood glucose lowering activity of some novel benzenesulfonylurea derivatives substituted with 6-aryl-4,5-dihyropyridazin-3(2H)-ones

Ist Teil von

• Medicinal chemistry research, 2012-12, Vol.21 (12), p.4352-4356

Ort / Verlag

New York: Springer-Verlag

Erscheinungsjahr

2012

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Five ( 2a–e ) benzenesulfonylurea derivatives bearing pyridazinone were synthesized by refluxing the appropriate 6-aryl-2-(p-sulfamylphenyl)-4,5-dihydropyridazine-3(2H)-one with benzylisocyanate in dry acetone over anhydrous K 2 CO 3 . These compounds were characterized by elemental analysis and various spectroscopic techniques viz; IR, 1 H NMR, 13 C NMR, and MS data. These compounds ( 2a–e ) at the dose of 20 mg/kg were tested for blood glucose lowering activity in glucose-fed hyperglycemic normal rats. Compound 2b showed more potent anti-hyperglycemic activity than the standard drug gliclazide. The compound 2b was also tested for its hypoglycemic effect in fasted normal rats. It also showed significant hypoglycemic effect (but less than that of gliclazide).