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Differential p53 protein expression in stomach adenomas of gastric and intestinal phenotypes : possible sequences of p53 alteration in stomach carcinogenesis
Ist Teil von
Virchows Archiv : an international journal of pathology, 1996-07, Vol.428 (4-5), p.223-227
Ort / Verlag
Berlin: Springer
Erscheinungsjahr
1996
Link zum Volltext
Quelle
SpringerLink (Online service)
Beschreibungen/Notizen
In a comparative study, the expression of p53 protein was investigated in intestinal- and gastric-type adenomas of the stomach. The former is a conventional type, which is well known to be a premalignant lesion of the stomach, but the latter is a rare, more recently noted entity. Of 28 intestinal-type adenomas, 17 (60.7%) contained more than 5% of p53 immunoreactive cells. In these adenomas, the extent of positivity for p53 protein was significantly higher in high-grade dysplasia than in low-grade dysplasia (P < 0.05), suggesting that p53 alteration plays a part in the dysplastic progression of intestinal-type adenomas. Among 18 gastric-type adenomas in which most of the tumour cells displayed gastric-type mucin, substantial expression of p53 protein was found only in the 3 tumours with high-grade dysplasia. Thus, the incidence of p53 expression was significantly higher in intestinal-type adenomas than in gastric-type adenomas (P < 0.01). These results suggest that p53 gene alteration is an earlier event in the gastric carcinogenetic sequence with the intestinal phenotype than in that with the gastric phenotype.