Details

Autor(en) / Beteiligte

• Lantto, E
• Järvi, K
• Krekelä, I
• Lantto, T
• Taavitsainen, M
• Vedenkangas, H
• Vorne, M

Titel

Technetium-99m hexamethyl propylene amine oxine leucocytes in the assessment of disease activity in inflammatory bowel disease

Ist Teil von

• European Journal of Nuclear Medicine, 1992, Vol.19 (1), p.14

Ort / Verlag

Germany

Erscheinungsjahr

1992

Quelle

MEDLINE

Beschreibungen/Notizen

• The inflammatory activity in 108 bowel segments of 40 patients with suspected or known inflammatory bowel disease was assessed macroscopically by endoscopy, histology and technetium-99m hexamethyl propylene amine oxine (99mTc-HMPAO) leucocytes using a numerical grading system (scores 0-3). A 4-h series of scintigrams showed a significant correlation with both histological and macroscopical assessment of disease activity (rho = 0.850, P less than 0.001 and rho = 0.773, P less than 0.001, respectively). Sensitivity, specificity and accuracy of scintigraphy in detecting active inflammatory segments were 85%, 92% and 89%, respectively. A normal scintigram did not completely exclude mild inflammatory activity, especially in the rectosigmoid area. 99mTc-HMPAO leucocytes offer an accurate and non-invasive alternative for the assessment of disease activity in ulcerative colitis and Crohn's disease.