Combined Effect of Propofol and GSNO on Oxidative Phosphorylation of Isolated Rat Liver Mitochondria
2001
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- Autor(en) / Beteiligte
- Titel
- Combined Effect of Propofol and GSNO on Oxidative Phosphorylation of Isolated Rat Liver Mitochondria
- Ist Teil von
- Nitric oxide, 2001-04, Vol.5 (2), p.158-165
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2001
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Isolated rat liver mitochondria have been treated with the general anaesthetic propofol (2,6-diisopropylphenol, 200 μM) and the physiological NO donor nitrosoglutathione (GSNO, 200 or 250 μM). The efficiency of the oxidative phosphorylation has been evaluated by measuring the respiration and ATP synthesis rates and the behavior of transmembrane electrical potential. In mitochondria energized by succinate, the simultaneous presence of both propofol and GSNO gives rise to a synergic action in affecting the resting and the ADP-stimulated respiration, the respiratory control ratio, the ATP synthesis, and the formation and utilization of the electrochemical transmembrane potential.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1089-8603eISSN: 1089-8611DOI: 10.1006/niox.2001.0331Titel-ID: cdi_crossref_primary_10_1006_niox_2001_0331
- Format
- –
- Schlagworte
- Adenosine Triphosphate - metabolism, Animals, Cell Respiration - drug effects, Drug Synergism, Free Radical Scavengers - pharmacology, Glutathione - analogs & derivatives, Glutathione - pharmacology, Kinetics, Membrane Potentials - drug effects, mitochondria, Mitochondria, Liver - drug effects, Mitochondria, Liver - metabolism, Nitric Oxide Donors - pharmacology, Nitroso Compounds - pharmacology, nitrosoglutathione, Oligomycins - pharmacology, oxidative phosphorylation, Oxidative Phosphorylation - drug effects, Oxygen Consumption - drug effects, propofol, Propofol - pharmacology, Rats, Rats, Wistar, S-Nitrosoglutathione, Uncoupling Agents - pharmacology