Details

Autor(en) / Beteiligte

• Riesewijk, Anne M.
• Schepens, Marga T.
• Mariman, Edwin M.
• Ropers, Hans-Hilger
• Kalscheuer, Vera M.

Titel

TheMASProto-Oncogene Is Not Imprinted in Humans

Ist Teil von

• Genomics (San Diego, Calif.), 1996-07, Vol.35 (2), p.380-382

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

1996

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Recently it was shown that the murineMasgene, which is located less than 300 kb from the imprintedIgf2rgene, is also imprinted in Day 11.5 embryos with expression exclusively from the paternal allele. We have assigned the humanMASgene to chromosomal bands 6q25.3–q26 in close proximity to theIGF2Rgene. In contrast to its murine homologue, the humanIGF2Rgene is not imprinted. By making use of a novel intragenic polymorphism, we have studied the expression of theMASgene in three heterozygous human fetuses. In all tissues examined, including tongue, biallelic expression of theMASgene was observed. Hence bothMASand the neighboringIGF2Rgene are not imprinted in humans.