Details

Autor(en) / Beteiligte

• De Die-Smulders, Christine E. M.
• Sturkenboom, Mirjam C. J. M.
• Veraart, Joep
• Van Katwijk, Cees
• Sastrowijoto, Prapto
• van der Linden, Ed

Titel

Severe limb defects and craniofacial anomalies in a fetus conceived during acitretin therapy

Ist Teil von

• Teratology (Philadelphia), 1995-10, Vol.52 (4), p.215-219

Ort / Verlag

New York: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

1995

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• We describe a 20‐week‐old fetus with multiple congenital anomalies exposed to acitretin in the first trimester of pregnancy. Acitretin and its ethylester etretinate are both vitamin A congeners; drugs of this group are well‐known teratogenic agents. Since the marketing of acitretin only one report on human teratogenicity associated with acitretin has been published. The present male fetus showed severe symmetric anomalies of upper and lower limbs, craniofacial anomalies, ear anomalies, and an atrioventricular septal defect (ASD). Although the craniofacial anomalies resemble the abnormalities described in classical “retinoic acid embryopathy,” limb anomalies were seldomly reported after maternal use of vitamin A congeners. However, in laboratory animals limb defects were frequently observed after retinoid exposure in utero. This case emphasizes again that extreme care and precaution are needed before prescribing a potentially teratogenic drug to a fertile woman. © 1995 Wiley‐Liss, Inc.