Details

Autor(en) / Beteiligte

• Liu, Li-Han
• Zhang, Yao-Hui
• Qiu, Wen-Xiu
• Zhang, Lu
• Gao, Fan
• Li, Bin
• Xu, Lu
• Fan, Jin-Xian
• Li, Zi-Hao
• Zhang, Xian-Zheng

Titel

Dual-Stage Light Amplified Photodynamic Therapy against Hypoxic Tumor Based on an O 2 Self-Sufficient Nanoplatform

Ist Teil von

• Small (Weinheim an der Bergstrasse, Germany), 2017-10, Vol.13 (37)

Ort / Verlag

Germany

Erscheinungsjahr

2017

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Tumor hypoxia severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a liposome-based nanoparticle (designated as LipoMB/CaO ) with O self-sufficient property for dual-stage light-driven PDT is demonstrated to address this problem. Through a short time irradiation, O activated by the photosensitizer methylene blue (MB) can induce lipid peroxidation to break the liposome, and enlarge the contact area of CaO with H O, resulting in accelerated O production. Accelerated O level further regulates hypoxic tumor microenvironment and in turn improves O generation by MB under another long time irradiation. In vitro and in vivo experiments also demonstrate the superior competence of LipoMB/CaO to alleviate tumor hypoxia, suppress tumor growth and antitumor metastasis with low side-effect. The O self-sufficient LipoMB/CaO nanoplatform with dual-stage light manipulation is a successful attempt for PDT against hypoxic tumor.