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differential effect of high and low molecular weight fucoidans on the severity of collagen-induced arthritis in mice
Phytotherapy research, 2010-09, Vol.24 (9), p.1384-1391
Park, Seung-Beom
Chun, Kwang-Rok
Kim, Jae-Kwan
Suk, Kyungho
Jung, Young-Mi
Lee, Won-Ha
2010
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Park, Seung-Beom
Chun, Kwang-Rok
Kim, Jae-Kwan
Suk, Kyungho
Jung, Young-Mi
Lee, Won-Ha
Titel
differential effect of high and low molecular weight fucoidans on the severity of collagen-induced arthritis in mice
Ist Teil von
Phytotherapy research, 2010-09, Vol.24 (9), p.1384-1391
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2010
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Fucoidans have been extensively studied for their various biological activities but the exact role of fucoidans on the inflammatory processes associated with arthritic disease has not been studied. The effect of the treatment of high, medium and low molecular weight fucoidans (HMWF, MMWF and LMWF, respectively) on the progression of collagen-induced arthritis (CIA) was tested. A daily oral administration of HMWF enhanced the severity of arthritis, inflammatory responses in the joint cartilage and the levels of collagen-specific antibodies, while LMWF reduced the severity of arthritis and the levels of Th1-dependent collagen-specific IgG₂a. Further in vitro analyses, using macrophage cell lines, revealed that the HMWF induced the expression of various inflammatory mediators, and enhanced the cellular migration of macrophages. These stimulatory effects of fucoidan decreased in fucoidans with lower molecular weights and LMWF did not exhibit any pro-inflammatory effects. Interestingly, the oral administration of HMWF enhanced the production of IFN-γ, one of the Th1 cytokines, in collagen-stimulated spleen cells that had been isolated from CIA mice, while LMWF had the opposite effect. These results indicate that HMWF enhances arthritis through enhancing the inflammatory activation of macrophages while LMWF reduces arthritis through the suppression of Th1-mediated Immune reactions. Copyright © 2010 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0951-418X
eISSN: 1099-1573
DOI: 10.1002/ptr.3140
Titel-ID: cdi_crossref_primary_10_1002_ptr_3140
Format
–
Schlagworte
Animals
,
Anti-Inflammatory Agents - pharmacology
,
Anti-Inflammatory Agents - therapeutic use
,
arthritis
,
Arthritis, Experimental - drug therapy
,
Arthritis, Experimental - immunology
,
Arthritis, Experimental - metabolism
,
Biological and medical sciences
,
Cartilage - drug effects
,
Cartilage - metabolism
,
Cartilage - pathology
,
Cell Movement - drug effects
,
Collagen Type II
,
fucoidan
,
General pharmacology
,
Immunoglobulin G - blood
,
inflammation
,
Inflammation - chemically induced
,
Inflammation - drug therapy
,
Inflammation - metabolism
,
Inflammation Mediators - metabolism
,
Interferon-gamma - biosynthesis
,
Joints - drug effects
,
Joints - metabolism
,
Joints - pathology
,
macrophage
,
Macrophages - drug effects
,
Macrophages - metabolism
,
Male
,
Medical sciences
,
Mice
,
Mice, Inbred DBA
,
Molecular Weight
,
Pharmacognosy. Homeopathy. Health food
,
Pharmacology. Drug treatments
,
Phytotherapy
,
Plant Extracts - pharmacology
,
Plant Extracts - therapeutic use
,
Polysaccharides - chemistry
,
Polysaccharides - pharmacology
,
Polysaccharides - therapeutic use
,
Severity of Illness Index
,
Spleen - cytology
,
Spleen - metabolism
,
Th1 Cells - metabolism
,
Undaria - chemistry
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