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Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension
Phytotherapy research, 2006-09, Vol.20 (9), p.732-736
Ferri, Letícia A. F.
Alves-Do-Prado, Wilson
Yamada, Sergio S.
Gazola, Sebastião
Batista, Marcia R.
Bazotte, Roberto B.
2006
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Ferri, Letícia A. F.
Alves-Do-Prado, Wilson
Yamada, Sergio S.
Gazola, Sebastião
Batista, Marcia R.
Bazotte, Roberto B.
Titel
Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension
Ist Teil von
Phytotherapy research, 2006-09, Vol.20 (9), p.732-736
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2006
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
The antihypertensive effect of crude stevioside obtained from the leaves of Stevia rebaudiana (Bertoni) Bertoni (Compositae) on previously untreated mild hypertensive patients was examined. Patients with essential hypertension were submitted to a placebo phase for 4 weeks. The volunteers selected in this phase were randomly assigned to receive either capsules containing placebo during 24 weeks or crude stevioside 3.75 mg/kg/day (7 weeks), 7.5 mg/kg/day (11 weeks) and 15.0 mg/kg/day (6 weeks). All capsules were prescribed twice a daily (b.i.d.), i.e. before lunch and before dinner. After the placebo phase and after each dose of crude stevioside, body mass index, electrocardiogram and laboratory tests were performed. During the investigation blood pressure (BP) was measured biweekly and the remaining data were collected at the end of each stevioside dose step. All adverse events were prospectively recorded but no major adverse clinical effects were observed during the trial. Systolic and diastolic BP decreased (p < 0.05) during the treatment with crude stevioside, but a similar effect was observed in the placebo group. Therefore, crude stevioside up to 15.0 mg/kg/day did not show an antihypertensive effect. Moreover, the results suggest that oral crude stevioside is safe and supports the well‐established tolerability during long term use as a sweetener in Brazil. Copyright © 2006 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0951-418X
eISSN: 1099-1573
DOI: 10.1002/ptr.1944
Titel-ID: cdi_crossref_primary_10_1002_ptr_1944
Format
–
Schlagworte
Adult
,
Antihypertensive Agents - analysis
,
Antihypertensive Agents - therapeutic use
,
Biological and medical sciences
,
blood pressure
,
clinical trial
,
Diterpenes, Kaurane - adverse effects
,
Diterpenes, Kaurane - therapeutic use
,
Double-Blind Method
,
Female
,
General pharmacology
,
Glucosides - adverse effects
,
Glucosides - therapeutic use
,
Humans
,
Hypertension - drug therapy
,
Male
,
Medical sciences
,
Middle Aged
,
Pharmacognosy. Homeopathy. Health food
,
Pharmacology. Drug treatments
,
Phytotherapy
,
placebo effect
,
Prospective Studies
,
Stevia - adverse effects
,
Stevia - chemistry
,
Stevia rebaudiana (Bertoni) Bertoni
,
stevioside
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