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Meta-analysis of the efficacy of the acetonic kava-kava extract WS®1490 in patients with non-psychotic anxiety disorders
Phytotherapy research, 2005-03, Vol.19 (3), p.183-188
Witte, Steffen
Loew, Dieter
Gaus, Wilhelm
2005
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Witte, Steffen
Loew, Dieter
Gaus, Wilhelm
Titel
Meta-analysis of the efficacy of the acetonic kava-kava extract WS®1490 in patients with non-psychotic anxiety disorders
Ist Teil von
Phytotherapy research, 2005-03, Vol.19 (3), p.183-188
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2005
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
Introduction: The herbal medicinal product kava‐kava, used for treating anxiety disorders, was assessed positively by the Cochrane Review. However, it was withdrawn from the market in Switzerland and Germany due to cases of liver failure and ‘unproven’ efficacy. Methods: A protocol for the meta‐analysis based on patient source data was written, a literature search was done, and six placebo‐controlled, randomized trials with the kava extract WS®1490 were identified. The endpoints were the change in HAMA during treatment (continuous and binary). Results: WS®1490 has an effective success rate of OR=3.3 (95% confidence interval of 2.09–5.22) in patients with non‐psychotic anxiety disorders. The continuous outcome supports this result: mean improvement with WS®1490 by 5.94 (95% confidence interval −0.86 to 12.8) points on the HAMA scale better than placebo. Kava seems to be more effective in females and in younger patients. Discussion: This meta‐analysis has no publication bias, no remarkable heterogeneity and is based on trials with high methodological standards. It is concluded that WS®1490, and possibly other kava extracts, are effective. Therefore they remain alternatives to benzodiazepines, selective serotonin re‐uptake inhibitors (SSRIs) and other antidepressants in the treatment of non‐psychotic anxiety disorders. Copyright © 2005 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0951-418X
eISSN: 1099-1573
DOI: 10.1002/ptr.1609
Titel-ID: cdi_crossref_primary_10_1002_ptr_1609
Format
–
Schlagworte
acetone kava extract
,
anxiety disorder
,
Biological and medical sciences
,
efficacy
,
General pharmacology
,
Hamilton anxiety score (HAMA)
,
Medical sciences
,
meta-analysis
,
Pharmacognosy. Homeopathy. Health food
,
Pharmacology. Drug treatments
,
phytotherapy
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