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Positive correlation between single or combined genotypes of CYP1A1 and GSTM1 in relation to prostate cancer in Chilean people
The Prostate, 2003-10, Vol.57 (2), p.111-117
Acevedo, Cristian
Opazo, Jose Luis
Huidobro, Christian
Cabezas, Juan
Iturrieta, Jeannette
Quiñones Sepúlveda, Luis
2003
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Acevedo, Cristian
Opazo, Jose Luis
Huidobro, Christian
Cabezas, Juan
Iturrieta, Jeannette
Quiñones Sepúlveda, Luis
Titel
Positive correlation between single or combined genotypes of CYP1A1 and GSTM1 in relation to prostate cancer in Chilean people
Ist Teil von
The Prostate, 2003-10, Vol.57 (2), p.111-117
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2003
Quelle
MEDLINE
Beschreibungen/Notizen
BACKGROUND The prostate cancer is a slowly progressing disease that begins decades prior to diagnosis. It has been suggested that there might be differences in susceptibility due to genetic polymorphisms in biotransformation enzyme genes. In the present work, associations between CYP1A1(Msp1), GSTM1(−/−) polymorphisms, and prostate cancer were analyzed in a case‐control study. METHODS Genomic DNA was isolated from peripheral blood samples, collected on EDTA. PCR‐RFLP was used to determine simultaneously Msp1 and GSTM1(−/−) polymorphisms. RESULTS In cancer patients, frequency of m2 variant allele (0.377) and GSTM1(−/−) (0.362) showed statistically significant increases compared to the control group (0.262 and 0.227, respectively). The estimate relative risks (OR) were higher for individuals carrying combined CYP1A1 and GSTM1 rare genotypes, in relation to individuals carrying CYP1A1 or GSTM1 alone. Multivariate logistic regression analysis including confounding factors (age, digital examination, and PSA antigen) showed even higher risk for individuals carrying m2m2 genotype (OR = 3.99; 95% CI, 1.27–12.54), GST(−/−) genotype (OR = 2.75; 95% CI, 1.31–5.79), and m2m2/GST(−) genotype (OR = 16.63; 95% CI, 1.67–165.48). CONCLUSIONS Taken together, these findings suggest that Chilean people carrying single or combined GSTM1 and CYP1A1 polymorphisms are more susceptible to prostate cancer. Prostate 57: 111–117, 2003. © 2003 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0270-4137
eISSN: 1097-0045
DOI: 10.1002/pros.10274
Titel-ID: cdi_crossref_primary_10_1002_pros_10274
Format
–
Schlagworte
Aged
,
Alleles
,
Case-Control Studies
,
Chile
,
CYP1A1
,
Cytochrome P-450 CYP1A1 - genetics
,
Gene Frequency
,
Genetic Predisposition to Disease
,
Genotype
,
Glutathione Transferase - genetics
,
GSTM1
,
Humans
,
Male
,
Middle Aged
,
Msp1
,
Multivariate Analysis
,
Polymerase Chain Reaction
,
Polymorphism, Genetic
,
Polymorphism, Restriction Fragment Length
,
polymorphisms
,
prostate cancer
,
Prostatic Neoplasms - genetics
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