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Pattern of adverse drug reactions to anti-epileptic drugs: a cross-sectional one-year survey at a tertiary care hospital
Pharmacoepidemiology and drug safety, 2008-08, Vol.17 (8), p.807-812
S, Roopa B.
Narayan, Sujatha S.
Sharma, G. R. K
Rodrigues, Rashmi J
Kulkarni, Chanda
2008
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
S, Roopa B.
Narayan, Sujatha S.
Sharma, G. R. K
Rodrigues, Rashmi J
Kulkarni, Chanda
Titel
Pattern of adverse drug reactions to anti-epileptic drugs: a cross-sectional one-year survey at a tertiary care hospital
Ist Teil von
Pharmacoepidemiology and drug safety, 2008-08, Vol.17 (8), p.807-812
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2008
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Purpose To investigate pattern and extent of adverse drug reactions (ADRs) associated with AEDs and to identify safer options for treatment of epilepsy. Method Study was a retrospective, cross‐sectional survey. Data from patients with epilepsy at the out‐patient and in‐patient of Neurology Department was collected in a specially designed proforma. Causality and severity of ADRs was categorized as per WHO guidelines. Results Among 788 patients with epilepsy, 80 (10.27%) had ADRs. ADRs with AED monotherapy were 9.18% and with polytherapy were 11.56%. ADRs with conventional and newer AED monotherapy was 10.24% and 6.84%, respectively, and were maximum with phenytoin and clobazam (14.28% and 12.5%). ADRs were mild in 4.16%, moderate in 70.83% and severe in 25% patients. Causality was probable in 65.62%, possible in 13.54% and definite in 20.83%. Patients (15/80) were hospitalized due to ADRs. Age and gender distribution showed statistically significant difference in occurrence of ADRs (p < 0.05). Chi‐square test for poly versus monotherapy and conventional versus newer AEDs did not show any significant difference. Conclusions Study showed maximum ADRs with AED polytherapy with no significant difference in frequency and severity of ADRs between conventional versus newer AEDs. This finding needs further investigation in larger number of patients to identify safer treatment options for epilepsy. Copyright © 2008 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 1053-8569
eISSN: 1099-1557
DOI: 10.1002/pds.1540
Titel-ID: cdi_crossref_primary_10_1002_pds_1540
Format
–
Schlagworte
Adolescent
,
Adult
,
adverse drug reaction
,
Aged
,
Aged, 80 and over
,
anti-epileptic drugs
,
Anticonvulsants - adverse effects
,
Child
,
Child, Preschool
,
Cross-Sectional Studies
,
Data Collection
,
Epilepsy - drug therapy
,
Female
,
Hospitals
,
Humans
,
Infant
,
Male
,
Middle Aged
,
monotherapy
,
polytherapy
,
Retrospective Studies
,
safer treatment options
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