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Hepatocyte-specific activation of NF-κB does not aggravate chemical hepatocarcinogenesis in transgenic mice
The Journal of pathology, 2009-02, Vol.217 (3), p.353-361
Yau, T.O
Chan, C.F
Gee-San Lam, S
Cheung, O.F
Ching, Y.P
Jin, D.Y
Sham, M.H
Ng, IOL
2009
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Yau, T.O
Chan, C.F
Gee-San Lam, S
Cheung, O.F
Ching, Y.P
Jin, D.Y
Sham, M.H
Ng, IOL
Titel
Hepatocyte-specific activation of NF-κB does not aggravate chemical hepatocarcinogenesis in transgenic mice
Ist Teil von
The Journal of pathology, 2009-02, Vol.217 (3), p.353-361
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2009
Quelle
Wiley-Blackwell subscription journals
Beschreibungen/Notizen
The NF-κB signalling pathway plays important roles in liver organogenesis and carcinogenesis. Mouse embryos deficient in IKKβ die in mid-gestation, due to excessive apoptosis of hepatoblasts. Although activation of the NF-κB signalling pathway has been demonstrated in human hepatocellular carcinoma, the role of NF-κB is controversial. Here, we have generated transgenic mice in which a constitutively active form of IKKβ was expressed in a hepatocyte-specific manner. Using electrophoretic mobility shift assay, we documented increased NF-κB activities and up-regulated levels of NF-κB downstream target genes, Bcl-xL and STAT5, in the transgenic mouse livers. These results confirmed that the NF-κB pathway was activated in the livers of the transgenic mice. However, there was no significant difference in tumour formation between transgenic and wild-type mice up to an age of 50 weeks. When we treated the transgenic mice with the chemical carcinogen diethylnitrosamine (DEN), we observed no significant differences in the incidence and size of liver tumours formed in these mice with and without DEN treatment at 35 weeks of age, suggesting that the activated NF-κB pathway in the livers of the transgenic mice did not enhance hepatocarcinogenesis. Interestingly, some of the transient transgenic embryos (E12.5) had abnormal excessive accumulation of nucleated red blood cells in their developing livers. In summary, NF-κB activation in hepatocytes did not significantly affect chemical hepatocarcinogenesis. In addition, the TTR/IKKCA transgenic mice may serve as a useful model for studying the role of NF-κB activation in hepatocarcinogenesis as well as inflammatory and metabolic diseases. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0022-3417
eISSN: 1096-9896
DOI: 10.1002/path.2451
Titel-ID: cdi_crossref_primary_10_1002_path_2451
Format
–
Schlagworte
Biological and medical sciences
,
chemical carcinogenesis
,
diethylnitrosamine
,
Gastroenterology. Liver. Pancreas. Abdomen
,
IKK
,
Investigative techniques, diagnostic techniques (general aspects)
,
IκB
,
liver
,
Liver. Biliary tract. Portal circulation. Exocrine pancreas
,
Medical sciences
,
NF-κB
,
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
,
signal transduction
,
Tumors
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