UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 18 von 1305
Datensatz exportieren als...
BibTeX
Dynamic intracellular survivin in oral squamous cell carcinoma: underlying molecular mechanism and potential as an early prognostic marker
The Journal of pathology, 2007-04, Vol.211 (5), p.532-540
Engels, K
Knauer, SK
Metzler, D
Simf, C
Struschka, O
Bier, C
Mann, W
Kovács, AF
Stauber, RH
2007
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Engels, K
Knauer, SK
Metzler, D
Simf, C
Struschka, O
Bier, C
Mann, W
Kovács, AF
Stauber, RH
Titel
Dynamic intracellular survivin in oral squamous cell carcinoma: underlying molecular mechanism and potential as an early prognostic marker
Ist Teil von
The Journal of pathology, 2007-04, Vol.211 (5), p.532-540
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2007
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Survivin functions as an apoptosis inhibitor and a regulator of cell division in many tumours. The intracellular localization of survivin in tumours has been suggested as a prognostic marker. However, current reports are inconsistent and the underlying molecular mechanisms are not understood. The present study has examined the localization and prognostic value of nuclear and cytoplasmic survivin in the pre‐therapeutic biopsies from 71 oral and oropharyngeal squamous carcinoma (OSCC) patients. Statistical analysis indicated that preferential nuclear versus cytoplasmic survivin correlated with favourable versus unfavourable disease outcome. Uni‐ and multi‐variate analysis showed that in contrast to total survivin expression, the difference between nuclear and cytoplasmic survivin was a strong predictor for relapse‐free survival (p = 0.0003). As a potential underlying molecular mechanism, it is shown in OSCC cell lines that predominantly cytoplasmic survivin mediates protection against chemo‐ and radio‐therapy‐induced apoptosis. Importantly, the cytoplasmic localization of survivin is regulated by its nuclear export signal (NES), and export‐deficient nuclear survivin is not cytoprotective. This study suggests that the difference between cytoplasmic and nuclear survivin is an indicator for survivin activity in tumour cells. Thus, this difference may serve as a predictive marker of outcome in OSCC patients undergoing multi‐modality therapy. The pharmacogenetic interference with survivin's cytoplasmic localization is also to be pursued as a potential therapeutic strategy. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0022-3417
eISSN: 1096-9896
DOI: 10.1002/path.2134
Titel-ID: cdi_crossref_primary_10_1002_path_2134
Format
–
Schlagworte
apoptosis
,
Apoptosis - physiology
,
Biological and medical sciences
,
Biomarkers, Tumor - analysis
,
cancer therapy
,
Carcinoma, Squamous Cell - chemistry
,
Carcinoma, Squamous Cell - drug therapy
,
Carcinoma, Squamous Cell - radiotherapy
,
cell cycle
,
Cell Line, Tumor
,
Cell Nucleus - chemistry
,
Cysteine Proteinase Inhibitors - analysis
,
Cytoplasm - chemistry
,
Exportin 1 Protein
,
head and neck cancer
,
Head and Neck Neoplasms - chemistry
,
Head and Neck Neoplasms - drug therapy
,
Head and Neck Neoplasms - radiotherapy
,
Humans
,
Immunohistochemistry - methods
,
Inhibitor of Apoptosis Proteins
,
Investigative techniques, diagnostic techniques (general aspects)
,
Kaplan-Meier Estimate
,
Karyopherins - analysis
,
Medical sciences
,
Microtubule-Associated Proteins - analysis
,
Mouth Neoplasms - chemistry
,
Mouth Neoplasms - drug therapy
,
Mouth Neoplasms - radiotherapy
,
Neoplasm Proteins - analysis
,
Nuclear Export Signals - physiology
,
Oropharyngeal Neoplasms - chemistry
,
Oropharyngeal Neoplasms - drug therapy
,
Oropharyngeal Neoplasms - radiotherapy
,
Otorhinolaryngology. Stomatology
,
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
,
Prognosis
,
Receptors, Cytoplasmic and Nuclear - analysis
,
Survivin
,
Tumors
,
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX