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Gains and losses of adhesion molecules (CD44, E-cadherin, and β-catenin) during oral carcinogenesis and tumour progression
The Journal of pathology, 2002-11, Vol.198 (3), p.343-351
Bánkfalvi, Agnes
Kraßort, Melanie
Buchwalow, Igor B.
Végh, Andras
Felszeghy, Endre
Piffkó, Jozsef
2002
Details
Autor(en) / Beteiligte
Bánkfalvi, Agnes
Kraßort, Melanie
Buchwalow, Igor B.
Végh, Andras
Felszeghy, Endre
Piffkó, Jozsef
Titel
Gains and losses of adhesion molecules (CD44, E-cadherin, and β-catenin) during oral carcinogenesis and tumour progression
Ist Teil von
The Journal of pathology, 2002-11, Vol.198 (3), p.343-351
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2002
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
The aim of this study was to define whether or not the impaired expression of CD44, E‐cadherin (E‐cad), and β‐catenin (β‐cat) correlates with the clinical evolution and prognosis of oral cancer. Ninety‐three primary oral squamous cell carcinomas (OSCCs) with tumour‐adjacent normal and/or dysplastic mucosa, 30 associated metastases, and 12 recurrences were immunostained for CD44s, ‐v3, ‐v4, ‐v5, ‐v6, ‐v7, ‐v9, E‐cad, and β‐cat. In non‐neoplastic epithelium, all molecules investigated were constitutively expressed in the basal layers. In the majority of dysplasias, immunoreactivity for all adhesion molecules was increased, but there was restricted loss for CD44s, E‐cad, and β‐cat in a few cases. In carcinomas, a striking accumulation of CD44s, v3, v4, v9 and a loss of E‐cad/β‐cat were observed at the invasive tumour front. In metastases and recurrences, besides a loss of CD44s, v4, v7, and E‐cad, a significant increase of v9 was recorded, whereas CD44v5 and v6 remained unchanged. Clinically, reduced expression of CD44v3, E‐cad, and changes of CD44v9 phenotype within the primary tumours correlated significantly with poor prognosis; decreased β‐cat expression was a predictive marker for nodal metastases. These findings indicate that there is some perturbed expression of adhesion molecules during the stepwise course of oral carcinogenesis and tumour progression. Distinct phenotypic alterations project poor prognosis, while others predict metastasis. Some of these restricted molecular changes may serve as potential targets for future antibody‐based tumour therapy. Copyright © 2002 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0022-3417
eISSN: 1096-9896
DOI: 10.1002/path.1204
Titel-ID: cdi_crossref_primary_10_1002_path_1204
Format
–
Schlagworte
beta Catenin
,
Biological and medical sciences
,
Biomarkers, Tumor - metabolism
,
Cadherins - metabolism
,
Carcinoma, Squamous Cell - metabolism
,
Carcinoma, Squamous Cell - pathology
,
Carcinoma, Squamous Cell - secondary
,
CD44
,
Cell Adhesion Molecules - metabolism
,
Cell Transformation, Neoplastic - metabolism
,
Cytoskeletal Proteins - metabolism
,
Disease Progression
,
E-cadherin
,
Female
,
Follow-Up Studies
,
Humans
,
Hyaluronan Receptors - metabolism
,
immunohistochemistry
,
Lymphatic Metastasis
,
Male
,
Medical sciences
,
Mouth Neoplasms - metabolism
,
Mouth Neoplasms - pathology
,
Neoplasm Proteins - metabolism
,
oral cancer
,
Otorhinolaryngology. Stomatology
,
Precancerous Conditions - metabolism
,
Prognosis
,
survival
,
Survival Rate
,
Trans-Activators - metabolism
,
Tumors
,
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
,
β-catenin
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