UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 16 von 90
Datensatz exportieren als...
BibTeX
Standardized T 2 map of normal human heart in vivo to correct T 2 segmental artefacts
NMR in biomedicine, 2007-10, Vol.20 (6), p.578-590
Positano, Vincenzo
Pepe, Alessia
Santarelli, Maria Filomena
Scattini, Barbara
De Marchi, Daniele
Ramazzotti, Anna
Forni, Gianluca
Borgna‐Pignatti, Caterina
Lai, Maria Eliana
Midiri, Massimo
Maggio, Aurelio
Lombardi, Massimo
Landini, Luigi
2007
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Positano, Vincenzo
Pepe, Alessia
Santarelli, Maria Filomena
Scattini, Barbara
De Marchi, Daniele
Ramazzotti, Anna
Forni, Gianluca
Borgna‐Pignatti, Caterina
Lai, Maria Eliana
Midiri, Massimo
Maggio, Aurelio
Lombardi, Massimo
Landini, Luigi
Titel
Standardized T 2 map of normal human heart in vivo to correct T 2 segmental artefacts
Ist Teil von
NMR in biomedicine, 2007-10, Vol.20 (6), p.578-590
Erscheinungsjahr
2007
Quelle
Wiley-Blackwell subscription journals
Beschreibungen/Notizen
Abstract A segmental, multislice, multi‐echo T 2 * MRI approach could be useful in heart iron‐overloaded patients to account for heterogeneous iron distribution, demonstrated by histological studies. However, segmental T 2 * assessment in heart can be affected by the presence of geometrical and susceptibility artefacts, which can act on different segments in different ways. The aim of this study was to assess T 2 * value distribution in the left ventricle and to develop a correction procedure to compensate for artefactual variations in segmental analysis. MRI was performed in four groups of 22 subjects each: healthy subjects (I), controls (II) (thalassemia intermedia patients without iron overload), thalassemia major patients with mild (III) and heavy (IV) iron overload. Three short‐axis views (basal, median, and apical) of the left ventricle were obtained and analyzed using custom‐written, previously validated software. The myocardium was automatically segmented into a 16‐segment standardized heart model, and the mean T 2 * value for each segment was calculated. Punctual distribution of T 2 * over the myocardium was assessed, and T 2 * inhomogeneity maps for the three slices were obtained. In group I, no significant variation in the mean T 2 * among slices was found. T 2 * showed a characteristic circumferential variation in all three slices. The effect of susceptibility differences induced by cardiac veins was evident, together with low‐scale variations induced by geometrical artefacts. Using the mean segmental deviations as correction factors, an artefact correction map was developed and used to normalize segmental data. The correction procedure was validated on group II. Group IV showed no significant presence of segmental artefacts, confirming the hypothesis that susceptibility artefacts are additive in nature and become negligible for high levels of iron overload. Group III showed a greater variability with respect to normal subjects. The correction map failed to compensate for these variations if both additive and percentage‐based corrections were applied. This may reinforce the hypothesis that true inhomogeneity in iron deposition exists. Copyright © 2007 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0952-3480
eISSN: 1099-1492
DOI: 10.1002/nbm.1121
Titel-ID: cdi_crossref_primary_10_1002_nbm_1121
Format
–
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX