Details

Autor(en) / Beteiligte

• Fenichel, Gerald M.
• Brooke, Michael H.
• Griggs, Robert C.
• Mendell, Jerry R.
• Miller, J. Phillip
• Moxley III, Richard T.
• Park, Jane H.
• Provine, Michael A.
• Florence, Julaine
• Kaiser, Kenneth K.
• King, Wendy M.
• Pandya, Shree
• Robison, Jenny
• Signore, Linda

Titel

Clinical investigation in Duchenne muscular dystrophy: Penicillamine and vitamin E

Ist Teil von

• Muscle & nerve, 1988-11, Vol.11 (11), p.1164-1168

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

1988

Quelle

MEDLINE

Beschreibungen/Notizen

• A double‐blind controlled trial of penicillamine and vitamin E against placebo was conducted in 106 boys with Duchenne muscular dystrophy. Nine dropped out of the study after being randomized. Patients were evaluated using an established protocol that measures muscle strength, joint contractures, functional grade, and pulmonary function. The trial lasted for 18 months. The power of the study to detect a 75% slowing of the disease was 0.95 at a P < 0.05. No therapeutic effect was observed in the patients taking penicillamine and vitamin E as compared with those taking placebo.