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Changes in tissue sodium concentration and sodium relaxation times during the maturation of human knee cartilage: Ex vivo 23 Na MRI study at 10. 5 T
Ist Teil von
Magnetic resonance in medicine, 2024-03, Vol.91 (3), p.1099-1114
Erscheinungsjahr
2024
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Abstract
Purpose
To evaluate the influence of skeletal maturation on sodium (
23
Na) MRI relaxation parameters and the accuracy of tissue sodium concentration (TSC) quantification in human knee cartilage.
Methods
Twelve pediatric knee specimens were imaged with whole‐body 10.5 T MRI using a density‐adapted 3D radial projection sequence to evaluate
23
Na parameters: B
1
+
, T
1
, biexponential , and TSC. Water, collagen, and sulfated glycosaminoglycan (sGAG) content were calculated from osteochondral biopsies. The TSC was corrected for B
1
+
, relaxation, and water content. The
literature‐based
TSC (TSC
LB
) used previously published values for corrections, whereas the
specimen‐specific
TSC (TSC
SP
) used measurements from individual specimens.
23
Na parameters were evaluated in eight cartilage compartments segmented on proton images. Associations between
23
Na parameters, TSC
LB
− TSC
SP
difference, biochemical content, and age were determined.
Results
From birth to 12 years, cartilage water content decreased by 18%; collagen increased by 59%; and sGAG decreased by 36% (all
R
2
≥ 0.557). The short () decreased by 72%, and the signal fraction relaxing with () increased by 55% during the first 5 years but remained relatively stable after that. TSC
SP
was significantly correlated with sGAG content from biopsies (
R
2
= 0.739). Depending on age, TSC
LB
showed higher or lower values than TSC
SP
. The TSC
LB
− TSC
SP
difference was significantly correlated with (
R
2
= 0.850), (
R
2
= 0.651), and water content (
R
2
= 0.738).
Conclusion
TSC and relaxation parameters measured with
23
Na MRI provide noninvasive information about changes in sGAG content and collagen matrix during cartilage maturation. Cartilage TSC quantification assuming fixed relaxation may be feasible in children older than 5 years.
Sprache
Englisch
Identifikatoren
ISSN: 0740-3194
eISSN: 1522-2594
DOI: 10.1002/mrm.29930
Titel-ID: cdi_crossref_primary_10_1002_mrm_29930
Format
–
Weiterführende Literatur
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