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In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes
Magnetic resonance in medicine, 2012-04, Vol.67 (4), p.1106-1113
Liu, Guanshu
Moake, Matthew
Har-el, Yah-el
Long, Chris M.
Chan, Kannie W.Y.
Cardona, Amanda
Jamil, Muksit
Walczak, Piotr
Gilad, Assaf A.
Sgouros, George
van Zijl, Peter C.M.
Bulte, Jeff W.M.
McMahon, Michael T.
2012
Details
Autor(en) / Beteiligte
Liu, Guanshu
Moake, Matthew
Har-el, Yah-el
Long, Chris M.
Chan, Kannie W.Y.
Cardona, Amanda
Jamil, Muksit
Walczak, Piotr
Gilad, Assaf A.
Sgouros, George
van Zijl, Peter C.M.
Bulte, Jeff W.M.
McMahon, Michael T.
Titel
In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes
Ist Teil von
Magnetic resonance in medicine, 2012-04, Vol.67 (4), p.1106-1113
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Link zum Volltext
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
A variety of (super)paramagnetic contrast agents are available for enhanced MR visualization of specific tissues, cells, or molecules. To develop alternative contrast agents without the presence of metal ions, liposomes were developed containing simple bioorganic and biodegradable compounds that produce diamagnetic chemical exchange saturation transfer MR contrast. This diamagnetic chemical exchange saturation transfer contrast is frequency‐dependent, allowing the unique generation of “multicolor” images. The contrast can be turned on and off at will, and standard images do not show the presence of these agents. As an example, glycogen, L‐arginine, and poly‐L‐lysine were encapsulated inside liposomes and injected intradermally into mice to image the lymphatic uptake of these liposomes. Using a frequency‐dependent acquisition scheme, it is demonstrated that multicolor MRI can differentiate between different contrast particles in vivo following their homing to draining lymph nodes. Being nonmetallic and bioorganic, these diamagnetic chemical exchange saturation transfer liposomes form an attractive novel platform for multicolor imaging in vivo. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0740-3194
eISSN: 1522-2594
DOI: 10.1002/mrm.23100
Titel-ID: cdi_crossref_primary_10_1002_mrm_23100
Format
–
Schlagworte
Animals
,
Cell Line, Tumor
,
CEST
,
Colorimetry - methods
,
Contrast Media - pharmacokinetics
,
liposome contrast agent
,
Liposomes - pharmacokinetics
,
lymph node imaging
,
Magnetic Resonance Imaging - methods
,
Magnetic Resonance Spectroscopy - methods
,
Mice
,
Mice, Inbred C57BL
,
molecular imaging
,
Molecular Imaging - methods
,
multicolor MR imaging
,
Neoplasms, Experimental - metabolism
,
Neoplasms, Experimental - pathology
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