Details

Autor(en) / Beteiligte

• Ratner, Adam V.
• Hurd, Ralph
• Muller, Holde H.
• Bradley‐Simpson, Beverly
• Pitts, William
• Shibata, J Dean
• Sotak, Chris
• Young, Stuart W.

Titel

19 F magnetic resonance imaging of the reticuloendothelial system

Ist Teil von

• Magnetic resonance in medicine, 1987-12, Vol.5 (6), p.548-554

Erscheinungsjahr

1987

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Abstract In this study sequential 1 H and 19 F magnetic resonance imaging methods were used to map the distribution of fluorinated compounds in vivo. An intravenously administered emulsion of perfluorooctylbromide (PFOB), an agent known to localize in the reticuloendothelial system, was detected in the liver and spleen of all studied hamsters and mice using 19 F MRI. Lungs and salivary glands were also affected in some animals. Using a G. E. NMR CSI 2‐T spectroscopy/imaging system, projection 19 F images were obtained in 4 to 8 min. Subsequent mouse studies using a thick‐slice driven equilibrium pulse sequence produced 19 F images with an improved signal‐to‐noise ratio in a shorter acquisition time. With PFOB, 19 F MRI has the capability of detecting macrophages in the reticuloendothelial system and in other sites where macrophages congregate. This is the first report where the reticuloendothelial system was specifically imaged in live animals and where driven equilibrium imaging techniques have been applied to 19 F MRI. © Academic Press, Inc.