Details

Autor(en) / Beteiligte

• Vandenbossche, Geert M.R.
• Lefebvre, Romain A.
• De Wilde, Gerda A.
• Remon, Jean-Paul

Titel

Performance of a Modified Starch Hydrophilic Matrix for the Sustained Release of Theophylline in Healthy Volunteers

Ist Teil von

• Journal of pharmaceutical sciences, 1992-03, Vol.81 (3), p.245-248

Ort / Verlag

Washington: Elsevier Inc

Erscheinungsjahr

1992

Quelle

MEDLINE

Beschreibungen/Notizen

• Two experimental formulations of theophylline with a hydrophilic starch matrix were evaluated for their sustained-release characteristics after single administration in healthy human volunteers. Theo-dur was chosen as a reference sustained-release formulation. In a first study, the extent of absorption was similar for a syrup, for Theo-dur, and for the experimental formulation of theophylline with 70% drum-dried corn starch as the sustained-release agent (DDCS-70). The maximal plasma concentration (Cmax was significantly lower, and the time to reach Cmax as well as the time span during which the plasma concentration was at least 75% of the Cmax were significantly higher for Theo-dur than for the DDCS-70 formulation. A sustained-release profile, as for Theo-dur, was not reached for DDCS-70. In a second study the influence of the starch:drug ratio on the bioavailability was investigated. The decrease in starch content from 70 to 50% of the formulation did not improve the plasma concentration-time profile towards a sustained-release profile.