Details

Autor(en) / Beteiligte

• Kosersky, Donald S.
• Brown, John K.
• Malone, Marvin H.

Titel

Effects of Cryogenine on Adjuvant-Induced Arthritis and Serum Turbidity in Rats

Ist Teil von

• Journal of pharmaceutical sciences, 1973-12, Vol.62 (12), p.1965-1968

Ort / Verlag

Washington: Elsevier Inc

Erscheinungsjahr

1973

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Daily oral administration of 100 mg./kg. of cryogenine significantly suppressed the inflammation and the development of disseminated lesions in rats with adjuvant-induced (Mycobacterium butyricum) polyarthritis. Significant anti-inflammatory effects continued for 10 days after cessation of therapy (20 days after pedal injection of adjuvant). Cryogenine also partially prevented the decreased growth rate and decreased serum turbidity documented for untreated rats with adjuvant-induced polyarthritis. This profile of activity was similar to that established for 10 mg./kg. daily of hydrocortisone but unlike that for 2 mg./kg. daily of mercaptopurine. Cryogenine appeared equipotent (milligrams per kilogram) to phenylbutazone in inhibiting adjuvant-induced polyarthritis.