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Dramatic Expansion and Developmental Expression Diversification of the M ethuselah Gene Family During Recent D rosophila Evolution
Journal of experimental zoology. Part B, Molecular and developmental evolution, 2012-07, Vol.318 (5), p.368-387
PATEL, MEGHNA V.
HALLAL, DANA A.
JONES, JEFFERY W.
BRONNER, DENISE N.
ZEIN, RAMI
CARAVAS, JASON
HUSAIN, ZAHABIYA
FRIEDRICH, MARKUS
VANBERKUM, MARK F.A.
2012
Details
Autor(en) / Beteiligte
PATEL, MEGHNA V.
HALLAL, DANA A.
JONES, JEFFERY W.
BRONNER, DENISE N.
ZEIN, RAMI
CARAVAS, JASON
HUSAIN, ZAHABIYA
FRIEDRICH, MARKUS
VANBERKUM, MARK F.A.
Titel
Dramatic Expansion and Developmental Expression Diversification of the M ethuselah Gene Family During Recent D rosophila Evolution
Ist Teil von
Journal of experimental zoology. Part B, Molecular and developmental evolution, 2012-07, Vol.318 (5), p.368-387
Erscheinungsjahr
2012
Link zum Volltext
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
ABSTRACT Functional studies of the methuselah/methuselah‐like ( mth / mthl ) gene family have focused on the founding member mth , but little is known regarding the developmental functions of this receptor or any of its paralogs. We undertook a comprehensive analysis of developmental expression and sequence divergence in the mth / mthl gene family. Using in situ hybridization techniques, we detect expression of six genes ( mthl1 , 5 , 9 , 11 , 13 , and 14 ) in the embryo during gastrulation and development of the gut, heart, and lymph glands. Four receptors ( mthl3 , 4 , 6 , and 8 ) are expressed in the larval central nervous system, imaginal discs, or both, and two receptors ( mthl10 and mth ) are expressed in both embryos and larvae. Phylogenetic analysis of all mth / mthl genes in five D rosophila species, mosquito and flour beetle structured the mth / mthl family into several subclades. mthl1 , 5 , and 14 are present in most species, each forming a separate clade. A newly identified D rosophila mthl gene ( CG 31720; herein mthl15 ) formed another ancient clade. The remaining D rosophila receptors, including mth , are members of a large “superclade” that diversified relatively recently during dipteran evolution, in many cases within the melanogaster subgroup. Comparing the expression patterns of the mth / mthl “superclade” paralogs to the embryonic expression of the singleton ortholog in T ribolium suggests both subfunctionalization and acquisition of novel functionalities. Taken together, our findings shed novel light on mth as a young member of an adaptively evolving developmental gene family. J. Exp. Zool. (Mol. Dev. Evol.) 318B:368‐387, 2012. © 2012 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1552-5007
eISSN: 1552-5015
DOI: 10.1002/jez.b.22453
Titel-ID: cdi_crossref_primary_10_1002_jez_b_22453
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