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Inhibition of long-term potentiation by CuZn superoxide dismutase injection in rat dentate gyrus: Involvement of muscarinic M1 receptor
Journal of cellular physiology, 2012-08, Vol.227 (8), p.3111-3115
Viggiano, A.
Serù, R.
Damiano, S.
De Luca, B.
Santillo, M.
Mondola, P.
2012
Details
Autor(en) / Beteiligte
Viggiano, A.
Serù, R.
Damiano, S.
De Luca, B.
Santillo, M.
Mondola, P.
Titel
Inhibition of long-term potentiation by CuZn superoxide dismutase injection in rat dentate gyrus: Involvement of muscarinic M1 receptor
Ist Teil von
Journal of cellular physiology, 2012-08, Vol.227 (8), p.3111-3115
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Long‐term potentiation (LTP) and long‐term depression represent important processes that modulate synaptic transmission that carries out a key role in neural mechanisms of memory. Many studies give strong evidences on a role of the reactive oxygen species in the induction of LTP in CA1 region of hippocampal slices that was inhibited by adding the scavenger enzyme superoxide dismutase (SOD1). Previous data showed that SOD1 is secreted by many cellular lines, including neuroblastoma SK‐N‐BE cells through microvesicles by an ATP‐dependent mechanism; moreover, it has been shown that SOD1 interacts with human neuroblastoma cell membranes increasing intracellular calcium levels via a phospholipase C–protein kinase C pathway activation. The aim of this study was to investigate the effect of intracerebral injection of SOD1 or the inactive form of enzyme (ApoSOD) on the modulation of synaptic transmission in dentate gyrus of the hippocampus in urethane anesthetized rats. The results of the present research showed that intracerebral injection of SOD1 and ApoSOD in the dentate gyrus of the rat hippocampal formation inhibits LTP induced by high‐frequency stimulation of the perforant path. This result cannot be only explained by the dismutation of oxygen radical induced by SOD1 since also ApoSOD, that lacks the enzymatic activity, carries out the same inhibitory effect on LTP induction. J. Cell. Physiol. 227: 3111–3115, 2012. © 2011 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0021-9541
eISSN: 1097-4652
DOI: 10.1002/jcp.23062
Titel-ID: cdi_crossref_primary_10_1002_jcp_23062
Format
–
Schlagworte
Animals
,
Cell Line, Tumor
,
Dentate Gyrus - metabolism
,
Gene Expression - drug effects
,
Humans
,
Long-Term Potentiation - drug effects
,
Male
,
Neuroblastoma - metabolism
,
Oligodendroglia - cytology
,
Oligodendroglia - metabolism
,
Rats
,
Rats, Sprague-Dawley
,
Receptor, Muscarinic M1 - metabolism
,
Superoxide Dismutase - administration & dosage
,
Superoxide Dismutase - chemistry
,
Superoxide Dismutase - metabolism
,
Synaptic Transmission - drug effects
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