Details

Autor(en) / Beteiligte

• He, Zhi-An
• Lu, Guang-Zhou
• Zhu, Lin-Lin
• Wang, Yong-Xue
• Yan, Fu-Lin
• Zhang, Ji-Xia

Titel

Antibacterial Constituents from Isodon Excisoides

Ist Teil von

• Journal of the Chinese Chemical Society (Taipei), 2010-04, Vol.57 (2), p.256-259

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2010

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• Two new ent‐kaurane diterpenoids, taihangexcisoidesin C (1) and its acetonide, taihangexcisoidesin D (2), along with 9 known compounds were isolated from the leaves of Isodon excisoides. The structures of the new compounds were elucidated using 1D and 2D NMR spectroscopy analysis. Compounds 3‐6 and 8‐9 were tested for their antibacterial activity against Escherichia coli, Staphylococcus aureus, S. epidermidis and S. saprophyticus. Compound 6 showed inhibitory effects on Staphylococcus aureus, S. epidermidis and S. saprophyticus MIC values 32, 16 and 16 μg/mL, respectively. All of the compounds didn't show effects on Escherichia coli (MIC > 10 mg/mL). Two new ent‐kaurane diterpenoids, taihangexcisoidesin C (1) and it's acetonide, taihangexcisoidesin D (2), along with 9 known compounds were isolated from the leaves of Isodon excisoides. The structures of the new compounds were elucidated using 1D and 2D NMR spectroscopy analysis. Compounds 3‐6 and 8‐9 were tested for their antibacterial activity against Escherichia coli, Staphylococcus aureus, S.epidermidis and S.saprophyticus.