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Stem cells: A minireview
Journal of cellular biochemistry, 2002, Vol.85 (S38), p.1-6
Jackson, Kathyjo A.
Majka, Susan M.
Wulf, Gerald G.
Goodell, Margaret A.
2002
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Jackson, Kathyjo A.
Majka, Susan M.
Wulf, Gerald G.
Goodell, Margaret A.
Titel
Stem cells: A minireview
Ist Teil von
Journal of cellular biochemistry, 2002, Vol.85 (S38), p.1-6
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2002
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
The identification of adult‐derived stem cells which maintain plasticity throughout the course of a lifetime, has transformed the field of stem cell biology. Bone marrow derived hematopoietic stem cells (HSC) are the most well‐characterized population of these multipotential cells. First identified for their ability to reconstitute blood lineages and rescue lethally irradiated hosts, these cells have also been shown to differentiate and integrate into skeletal muscle, cardiac myocytes, vascular endothelium, liver, and brain tissue. Various populations of HSC are being studied, exploiting cell surface marker expression, such as Sca‐1, c‐kit, CD34, and lin−; as well as the ability to efflux the vital dye Hoecsht 33342. Detection of engrafted donor derived cells into various tissue types in vivo is a laborious process and may involve detection of β‐galactosidase via colorimetric reaction or antibody labeling or green fluorescent protein (GFP) via fluorescence microscopy, as well as in situ hybridization to detect the Y‐chromosome. Using these techniques, the search has begun for tissue specific stem cells capable of host tissue regeneration, self renewal, and transdifferentiation. Caution is urged when interpreting these types of experiments because although they are stimulating, limitations of the technologies may provide misleading results. J. Cell. Biochem. Suppl. 38: 1–6, 2002. © 2002 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0730-2312, 0733-1959
eISSN: 1097-4644
DOI: 10.1002/jcb.10045
Titel-ID: cdi_crossref_primary_10_1002_jcb_10045
Format
–
Schlagworte
Animals
,
Cell Differentiation
,
Cell Separation - methods
,
Cell- and Tissue-Based Therapy
,
Hematopoietic Stem Cells - cytology
,
Hematopoietic Stem Cells - physiology
,
Humans
,
injury repair
,
Molecular Probes
,
Multipotent Stem Cells - cytology
,
Multipotent Stem Cells - physiology
,
Multipotent Stem Cells - transplantation
,
Stem Cell Transplantation
,
stem cells
,
tissue plasticity
,
transdifferentiation
,
Wound Healing
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