Details

Autor(en) / Beteiligte

• Rocha, Raquel G.
• Stefano, Jéssica S.
• Arantes, Iana V. S.
• Ribeiro, Michelle M. A. C.
• Santana, Mario H. P.
• Richter, Eduardo M.
• Munoz, Rodrigo A. A.

Titel

Simple Strategy for Selective Determination of Levamisole in Seized Cocaine and Pharmaceutical Samples Using Disposable Screen‐printed Electrodes

Ist Teil von

• Electroanalysis (New York, N.Y.), 2019-01, Vol.31 (1), p.153-159

Erscheinungsjahr

2019

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Levamisole is the most common adulterant found in cocaine samples and its electrochemical determination in cocaine seized samples is a challenge due to peak overlapping with cocaine. Herein, we propose a deconvolution procedure for levamisole determination in seized cocaine samples using screen‐printed carbon electrodes (SPE). Square‐wave voltammetry in 0.04 mol L−1 Britton Robinson buffered solution (pH 8.0) was selected in combination with optimized SWV parameters (f=8 s−1, a=10 mV and ΔEs=1 mV) to result in the best peak resolution to apply the deconvolution procedure. Deconvoluted responses of levamisole in the presence of cocaine were similar to untreated signals of standard levamisole solutions in absence of cocaine. A linear response was obtained in the range of 20–100 μmol L−1 (r=0.995). The results obtained for the analysis of a seized cocaine sample was statistically similar to that obtained by gas chromatography. Other adulterants found in cocaine street samples (paracetamol, glucose, phenacetin, caffeine, boric acid and lidocaine) did not affect the treated of voltammetric responses of levamisole. A pharmaceutical sample containing levamisole was also analyzed on SPEs and a recovery of 93±2 % was obtained (no deconvolution required for this sample), showing great applicability of SPEs for forensic and pharmaceutical analyses.