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Modification of Pyrrolo[2,1‐a]isoquinolines through Iron‐Catalyzed Aminomethylenation with Amines and Dimethyl Sulfoxide
Ist Teil von
European journal of organic chemistry, 2022-08, Vol.2022 (31), p.n/a
Erscheinungsjahr
2022
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Modification of pyrrolo[2,1‐a]isoquinolines through Fe(OTf)3 catalyzed aminomethylenation with amines and dimethyl sulfoxide has been realized. A series of highly functionalized pyrroloisoquinolines have been prepared in acceptable to good yields (17–72 % yields). Dimethyl sulfoxide serves as the source of methylene group under a catalytic system. Lactam‐fused pyrrolo[2,1‐a]isoquinoline can be obtained through simple chemical transformation.
In this work, modification of pyrrolo[2,1‐a]isoquinolines through Fe(OTf)3 catalyzed aminomethylenation with amines and dimethyl sulfoxide has been realized.