Details

Autor(en) / Beteiligte

• Gansäuer, Andreas
• Justicia, José
• Rosales, Antonio
• Worgull, Dennis
• Rinker, Björn
• Cuerva, Juan Manuel
• Oltra, Juan Enrique

Titel

Transition-Metal-Catalyzed Allylic Substitution and Titanocene-Catalyzed Epoxypolyene Cyclization as a Powerful Tool for the Preparation of Terpenoids

Ist Teil von

• European Journal of Organic Chemistry, 2006-09, Vol.2006 (18), p.4115-4127

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2006

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Many biologically active substances are composed of sesquiterpene units linked to aromatic structures, especially substituted phenols. Here, we describe an efficient synthetic approach to this class of natural product from commercially available substances in a short sequence. The key transformations involve allylic substitution reactions using a palladium or copper catalyst and titanocene‐catalyzed epoxypolyene cyclization reactions via radicals. The polycyclic core structures are accessed with high chemo‐ and stereocontrol. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)